Vaccines, transplants and donation

Explain what a vaccine is, what it contains, and how it prepares the body to defend itself against a disease without suffering from it.

Explain the difference between preventing a disease and curing it, using a vaccine and a medicine as examples.

Explain what mild side effects can appear in the days after a vaccine and why they are usually a sign that the immune system is responding.

The tetanus vaccine requires booster doses every few years, whereas others provide lifelong protection with few doses. Explain, based on how immunological memory works, why some protection weakens over time.

The flu vaccine is given every autumn, whereas the measles vaccine is given in childhood and protects for decades. Explain, relating it to the characteristics of each virus and to immune memory, why some vaccines must be repeated and others do not.

A research team develops two experimental vaccines against a new respiratory virus: vaccine A uses the whole attenuated virus, while vaccine B introduces only fragments of the external protein that the virus uses to attach to human cells (surface antigen).

1. a) Justify why the body of a person who receives vaccine B will be able to neutralise the real virus if they come into contact with it later on, even though the vaccine only contained a fragment.
2. b) During trials, it is observed that in immunocompromised patients, vaccine A can cause mild symptoms of the disease, while vaccine B is completely harmless but requires a booster dose. With this data, justify which of the two vaccines you would recommend administering as a priority in a hospital to elderly people or those with weakened immune systems.

On an internet forum you read this statement: "We shouldn't get the new vaccine against pathogen X. In its clinical trial with 10,000 volunteers, 0.3 % developed fever and muscle pain. A safe vaccine should have zero risk before being authorised."

1. a) Knowing that natural infection by pathogen X causes severe complications in 8 out of every 100 infected people (8 %), compare both figures and explain what the benefit-risk balance means in the authorisation of medicines.
2. b) Refute the statement by arguing biologically why it is impossible to guarantee "zero risk" in any medical treatment and what guarantees the phases of clinical trials provide before a vaccine reaches the general population.

State what a vaccination schedule is, why there are vaccines administered at specific ages, and name two vaccines included in Ireland's childhood and adolescent vaccination schedule.

State whether these statements are true or false and justify your answer: a) getting vaccinated also indirectly protects people who cannot be vaccinated; b) donating blood weakens the donor for months; c) in Ireland organ donation is altruistic and is not paid for.

The two diagrams represent the same outbreak in two populations with different vaccination coverage (green: vaccinated people; grey: unvaccinated people; red: infected people; the orange crosses in diagram A indicate blocked transmissions). Explain why in diagram A the infection does not advance whereas in B it spreads in a chain reaction, what this "herd immunity" consists of, and what risk is posed by a decrease in vaccination coverage.

Explain why babies start being vaccinated in the first months of life, which serious diseases are avoided in this way, and what risk delaying the vaccination schedule would have.

A person claims: "I don't get vaccinated because I never get ill". Analyse this argument taking herd immunity into account, and reason what would happen if many people thought the same way.

Measles is one of the most contagious viruses in existence: to maintain community or herd immunity and halt its transmission, at least 95 % of the population needs to be vaccinated. In a town of 20,000 inhabitants, vaccination coverage has dropped to 86 % over the last two years. Living in this town are Aoife, a 4-month-old baby who is not yet old enough to be vaccinated, and Cian, a boy undergoing cancer treatment who cannot receive the vaccine because of a weakened immune system.

1. a) Predict what will happen in that town if a person infected with measles attends a crowded party, comparing the current scenario (86 %) with the previous one (95 %).
2. b) Based on the case of Aoife and Cian, justify biologically why a person's decision not to get vaccinated is not just an individual choice regarding their own health, but directly endangers the most vulnerable members of the community.

During a global epidemic of an airborne virus, Country A (high-income) has managed to vaccinate 85 % of its population, while Country B (low-income) has only been able to access vaccines for 4 % of its inhabitants. The authorities of Country A decide to suspend their contributions to international vaccine donation funds, arguing: "Our population is already safe; spending money on other countries adds nothing to our own health security."

1. a) Refute the stance of Country A's authorities by applying your knowledge of viral reproduction, mutations, and the emergence of new variants.
2. b) Justify, from a biological and epidemiological point of view, the validity of the scientific principle: "In a global pandemic, no one is completely safe until everyone is safe."

Explain what it means to be a blood donor, what basic requirements are asked of donors, and why regular donation is necessary even when there are no emergencies.

Name three donations a person can make to help other patients and state what type of patients each one helps.

Explain what blood groups are, why it is essential to know them before a transfusion, and which group can donate red blood cells to anyone.

In Ireland, a person can donate blood from the age of 18 if they meet the requirements. Each donation (about $450\ \text{mL}$) is separated into three components (red blood cells, plasma, and platelets) and can help up to three patients, but these components expire: platelets last only about $5$ days and red blood cells about six weeks. If a hospital needs $25$ units of blood components per day, calculate how many donations are needed as a minimum each week and reason, based on the expiration of the components, why donating only after major disasters is not enough.

Explain what a transplant is and cite two organs or tissues that are frequently transplanted, indicating which health problem each one solves.

Rejection can occur in an organ transplant. Explain why the recipient's immune system attacks the transplanted organ, what blood groups and compatibility are, and what medications are used to prevent rejection.

Explain what bone marrow donation consists of, what type of patients it can cure, and why it is so difficult to find a compatible donor.

In a hospital, brain death (the irreversible cessation of all brain activity, maintaining oxygenation and heartbeat through artificial life support) is certified in a young patient following an accident. The patient left no document stating their wishes regarding organ donation. In Ireland, "presumed consent" applies, whereby every person is a donor unless they expressed the contrary in life. However, the transplant coordination team always meets with the family to ask for their consent before proceeding.

1. a) The family, in shock, is hesitant because they see that the monitor shows a pulse and they believe that the patient "could still wake up". Justify what medical and biological arguments the coordinator should provide to explain the difference between a reversible coma and brain death.
2. b) Reason why you think the Irish model always seeks agreement with the family instead of applying the law automatically and compulsorily, and what consequences acting without their consent would have on public trust in the healthcare system.

Aoife suffers from severe kidney failure and her kidneys barely filter waste from her blood. Her brother Seán, who is completely healthy, offers to be a living kidney donor. However, the hospital spends weeks conducting exhaustive blood and immunological compatibility tests (leukocyte antigens) before authorizing the procedure.

1. a) Predict and explain what would happen at the cellular level in Aoife's body if her brother's kidney were transplanted without prior verification of their antigen compatibility.
2. b) If the surgery is successful, how is it possible for Seán to continue leading a normal and healthy life with only one kidney? Justify how his body responds to maintain blood filtration and homeostasis.

Tumour cells originate from the body's own tissues that have mutated and escaped division control. Many of them develop a "camouflage" protein on their cell membrane that, upon binding to T lymphocytes, deactivates them and prevents them from destroying the tumour cells. Recently, immunotherapy drugs consisting of monoclonal antibodies that block this camouflage protein have been developed.

1. a) Explain why a traditional preventive vaccine (such as the measles or tetanus vaccine) is not effective in preventing most cancers, pointing out the fundamental difference between the origin of antigens from an invading microbe and those from a tumour cell.
2. b) Predict what effect the described immunotherapy drug will have on the tumour once administered to the patient, and justify why this treatment usually damages healthy tissues far less than classic methods such as chemotherapy.

Unit challenge. Become a public health advisor for your town by designing a community awareness campaign.

1. Check on the official Organ Donation Transplant Ireland (ODTI) website the organ donor rate for Ireland in 2023 and compare it with Spain's average for that same year ($48.9$ donors per million inhabitants). In addition, survey $4$ family members, asking them which diseases (infectious or non-infectious) they have had this year and their vaccination status.

2. Organize the survey data in a table. In a short text, describe how the body's defenses (barriers or antibodies) acted against one of the recorded infections and justify the immunological memory mechanism provided by vaccines.

3. Create a digital brochure titled "Health and Solidarity" where you propose daily guidelines to prevent non-infectious diseases, explain the collective benefit of vaccination, and provide two arguments to promote organ and tissue donation to address the need for transplants.

Assessment criteria:

• Thorough distinction between pathologies and correct explanation of the immune response and vaccines.

• Adequate collection, comparison, and analysis of data from the ONT and the survey.

• Scientific consistency, creativity, and clarity of the final proposal.