Other patterns of inheritance
Not all characteristics are inherited like the colour of Mendel's peas. Some flowers come out pink when a red one is crossed with a white one, and there are diseases that almost only affect men. Genetics has more patterns than simple dominance.
Codominance
When a black bull is crossed with a white Shorthorn cow, the calves are born with white and black hairs clearly intermingled, without forming a grey shade. How can it be explained that the characteristics of both parents show up at the same time without one hiding the other?
Explain what codominance is and give a human example in which two alleles are expressed simultaneously.
Explain what codominance is and give a human example in which two alleles are expressed simultaneously.
Explain what incomplete dominance is and describe which phenotype appears when crossing a red-flowered plant with a white-flowered plant if the trait follows this…
Explain what incomplete dominance is and describe which phenotype appears when crossing a red-flowered plant with a white-flowered plant if the trait follows this pattern.
Intermediate inheritance
When a pure red-flowered four o'clock plant is crossed with a pure white-flowered one, 100 % of the offspring have flowers of a uniform pink colour. Why does the colour of neither parent predominate, and why does a halfway phenotype appear?
The alleles $I^A$, $I^B$ and $i$ are involved in blood groups. State which genotypes correspond to blood groups A, B, AB and O.
The alleles $I^A$, $I^B$ and $i$ are involved in blood groups. State which genotypes correspond to blood groups A, B, AB and O.
A person with blood group AB and a person with blood group O have a child. State the possible blood groups of the child and their probabilities, excluding each parent's…
A person with blood group AB and a person with blood group O have a child. State the possible blood groups of the child and their probabilities, excluding each parent's blood group from the possibilities.
In four o'clock plants, flower colour shows incomplete dominance: red (RR), pink (Rr) and white (rr). Complete the Punnett square in the diagram, where two pink-flowered…
In four o'clock plants, flower colour shows incomplete dominance: red (RR), pink (Rr) and white (rr). Complete the Punnett square in the diagram, where two pink-flowered plants are crossed, and state the genotypic and phenotypic ratios of the offspring.
Sex-linked inheritance
In the family trees of affected families, disorders such as colour blindness or haemophilia appear almost exclusively in males, while females are usually only symptom-free carriers. Why is an inherited characteristic distributed so unevenly between the two sexes?
Explain the difference between codominance and incomplete dominance, and give an example of each one.
Explain the difference between codominance and incomplete dominance, and give an example of each one.
In humans, sex is determined chromosomally: females are XX and males are XY. Explain, using the corresponding cross, why the probability of having a son or a daughter is…
In humans, sex is determined chromosomally: females are XX and males are XY. Explain, using the corresponding cross, why the probability of having a son or a daughter is equal (1:1 ratio) and which parent provides the chromosome that determines the sex of the offspring.
A couple attends a genetic counseling consultation: the man has normal vision and so does the woman, but she is concerned because her maternal grandfather was…
A couple attends a genetic counseling consultation: the man has normal vision and so does the woman, but she is concerned because her maternal grandfather was color-blind (her maternal grandmother and her father had normal vision and had no family history). The man claims there is nothing to worry about, stating: "Since I am not color-blind, it is impossible for us to have a color-blind daughter or son."
- a) Reasonably deduce the probability that the woman is a carrier based on the data from her maternal family.
- b) Refute or validate the man's claim using genetic arguments for daughters and sons separately, showing the possible crosses.
- c) Calculate the final probability that the first child born to this couple is a color-blind male.
Mutations, the origin of new alleles
Explain what it means for a gene to be linked to the X chromosome and reason why men (XY) have only one allele for those genes, while women (XX) have two.
Explain what it means for a gene to be linked to the X chromosome and reason why men (XY) have only one allele for those genes, while women (XX) have two.
In Andalusian hens, plumage colour shows incomplete dominance: BB is black, Bb is blue and bb is white. Cross two blue hens and state the expected genotypic and…
In Andalusian hens, plumage colour shows incomplete dominance: BB is black, Bb is blue and bb is white. Cross two blue hens and state the expected genotypic and phenotypic ratios in the chicks.
A medical emergency occurs in a hospital and a patient with blood type 0 urgently needs a transfusion. When testing their biological parents, it is found that the father…
A medical emergency occurs in a hospital and a patient with blood type 0 urgently needs a transfusion. When testing their biological parents, it is found that the father is type A and the mother is type B. A student intern claims that there must be an error in parentage, arguing that "two parents with dominant A and B antigens can never produce a type 0 child, who lacks both antigens."
- a) Refute the student's statement by deducing the exact genotypes that the parents must have, and represent the cross that demonstrates the genetic viability of the patient's birth.
- b) If this same couple has more offspring, predict the expected phenotypic percentages for each blood type.
- c) Justify whether any of the future siblings could donate red blood cells to the type 0 patient.
Multiple alleles: ABO blood groups
A gene can have more than two alleles in the population, although each diploid individual has only two. In the ABO model, $I^A$ and $I^B$ are codominant and both dominate over $i$.
Back to the beginning: Pink flowers are the result of intermediate inheritance (the heterozygote produces an intermediate amount of pigment), whereas diseases that affect almost only men are due to recessive alleles on the X chromosome, where they do not have a second X chromosome to compensate for them.